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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
9.09
Human Site:
Y356
Identified Species:
15.38
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
Y356
N
N
R
G
K
K
R
Y
P
D
S
K
D
L
T
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
Y356
N
N
R
G
K
K
R
Y
P
D
S
K
D
L
T
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
V356
K
N
H
R
K
L
R
V
P
D
R
N
S
Q
T
Dog
Lupus familis
XP_534917
565
65190
G400
K
N
M
T
N
N
R
G
K
K
R
Y
P
D
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
G467
K
N
I
N
N
N
R
G
G
K
R
Y
P
D
S
Rat
Rattus norvegicus
Q4V8A3
586
65492
D412
Q
P
L
F
P
G
E
D
E
G
D
Q
L
A
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
P303
P
E
V
I
L
G
R
P
Y
D
T
A
I
D
M
Chicken
Gallus gallus
Q5ZIU3
526
59419
E361
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
P
Frog
Xenopus laevis
Q2TAE3
750
84138
S494
T
S
P
A
M
E
Q
S
Q
S
S
G
T
T
S
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
R464
N
S
K
G
K
K
R
R
P
S
S
K
D
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
S450
N
T
K
G
R
K
R
S
P
G
S
K
S
L
A
Honey Bee
Apis mellifera
XP_396369
614
68978
W432
N
S
K
G
K
K
R
W
A
G
S
R
N
L
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
I237
K
S
S
A
I
K
L
I
D
F
G
S
T
V
C
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
M621
S
S
T
Q
K
H
R
M
K
T
I
E
E
F
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
40
13.3
N.A.
13.3
0
N.A.
13.3
0
6.6
66.6
N.A.
53.3
46.6
N.A.
N.A.
P-Site Similarity:
100
100
40
20
N.A.
20
6.6
N.A.
20
6.6
33.3
80
N.A.
66.6
80
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
22
0
0
0
0
8
0
0
8
0
8
22
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
22
% C
% Asp:
8
0
0
0
0
0
0
8
8
29
8
0
22
22
0
% D
% Glu:
0
8
0
0
0
8
8
8
8
0
0
8
8
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
8
0
0
0
8
0
% F
% Gly:
0
0
0
36
0
15
0
15
8
22
15
8
0
0
0
% G
% His:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
8
8
0
8
8
0
0
8
0
8
0
0
% I
% Lys:
29
0
22
0
43
43
0
0
15
15
0
29
0
0
0
% K
% Leu:
0
0
15
0
8
8
8
0
8
8
0
0
8
36
0
% L
% Met:
0
0
8
0
8
8
0
8
0
0
0
8
0
0
8
% M
% Asn:
36
36
0
8
15
15
0
0
0
0
0
8
8
0
0
% N
% Pro:
8
8
8
0
8
0
0
8
36
0
0
0
22
0
8
% P
% Gln:
8
8
0
8
0
0
8
0
8
0
0
8
0
8
0
% Q
% Arg:
0
0
15
8
8
0
72
8
0
0
22
8
0
0
0
% R
% Ser:
8
36
8
0
0
0
0
15
0
15
43
8
15
8
22
% S
% Thr:
8
8
8
8
0
0
0
0
0
8
8
0
15
8
22
% T
% Val:
0
0
8
0
0
0
0
8
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
15
8
0
0
15
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _